The granulocyte colony-stimulating factor receptor (GCSFR), also known as CSF3R or CD114, is an important regulator of granulopoiesis. Recent research suggests that it is overexpressed in a variety of cancer types, where it promotes tumor growth by affecting both myeloid and non-myeloid immune cells. Given its relevance in carcinogenesis, GCSFR is a promising therapeutic target for the development of novel anticancer medicines.